Published! (Since 2009; students, PDF's and RA's are in bold, last author = corresponding authorship. Researcher ID: D-5684-2012)
2024
Nie DY, Tabor JR, Li J, Kutera M, St-Germain J, Hanley RP, Wolf E, Paulakonis E, Kenney TMG, Duan S, Shrestha S, Owens DDG, Maitland MER, Pon A, Szewczyk M, Lamberto AJ, Menes M, Li F, Penn LZ, Barsyte-Lovejoy D, Brown NG, Barsotti AM, Stamford AW, Collins JL, Wilson DJ, Raught B, Licht JD, James LI and Arrowsmith CH (2024) "Recruitment of FBXO22 for targeted degradation of NSD2", Nat Chem Biol, doi: 10.1038/s41589-024-01660-y (link)
Listigovers A, Lento C and Wilson DJ (2024) "Distinct antithrombin activation modes for fondaparinux and natural heparins detected using millisecond hydrogen deuterium exchange and collision induced unfolding", Int J Biol Macromol, https://doi.org/10.1016/j.ijbiomac.2024.132868 (link)
Dvořák Z, ... Chow V, ... Wilson DJ, ... Mani S (2024) "In vitro safety signals for potential clinical development of the anti-inflammatory pregnane X receptor agonist FKK6", Bioorg Chem, doi: 10.1016/j.bioorg.2024.107137 (link)
Mann MK, Wolf E, Silva M, Kwak HA, Wilson B, Bolotokova A, Wilson DJ, Harding RJ and Schapira M (2024) "Small Molecule Screen Identifies Non-catalytic USP3 Chemical Handle", ACS Omega, https://doi.org/10.1021/acsomega.3c07070 (link)
Liu J, Malekoltojari A, Asokakumar A, Chow V, Li L, Li H, Grimaldi M, Dang N, Campbell J, Barrett H, Sun J, Navarre W, Wilson D, Wang H, Mani S, Balaguer P, Anakk S, Peng H and Krause HM (2024) "Diindoles produced from commensal microbiota metabolites function as endogenous CAR/Nr1i3 ligands", Nat Commun, doi: 10.1038/s41467-024-46559-3 (link)
2023
Hermet P, ... Wolf E, ... Wilson DJ, ... Ustav Jr. M (2023) "Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates", PLoS Pathog (link)
Wolf E, Lento C, Pu J, Dickinson BC and Wilson DJ (2023) Innate Conformational Dynamics Drive Binding Specificity in Anti-Apoptotic Proteins Mcl-1 and Bcl-2", Biochemistry (link)
Anacleto J, Lento C, Sarpe V, Maqsood A, Mehrazma B, Schriemer D and Wilson DJ (2023) "Apparatus for Automated Continuous Hydrogen Deuterium Exchange Mass Spectrometry Measurements from Milliseconds to Hours", Anal Chem (link)
Miller JJ, Kwan K, Blanchet A, Orvain C, Mellitzer G, Smith J, Lento C, Nouchikian L, Omoregbee-Leichnitz S, Sabatou M, Wilson DJ, Gaiddon C and Storr T (2023) "Multifunctional metallochaperone modifications for targeting subsite cavities in mutant p53-Y220C", J Inorg Biochem (link)
Chow V, Wolf E, Lento C and Wilson DJ (2023) "Developments in rapid hydrogen–deuterium exchange methods", Essays Biochem (link)
2022
Mckerchar HJ, Lento C, Bennie RZ, Crowther JM, Dolamore F, JM Dyer, Clerens S, Mercadante D, Wilson DJ and Dobson RCJ (2022) "The protein dynamics of bovine and caprine β-lactoglobulin differ as a function of pH", Food Chemistry (link)
Balachandran N, Grainger RA, Rob T, Liuni P, Wilson DJ, Junop MS and Berti PJ (2022) "Role of Half-of-Sites Reactivity and Inter-Subunit Communications in DAHP Synthase Catalysis and Regulation", Biochemistry (link)
Zhu S, Liuni P, Chen T, Houy C, Wilson DJ and James DA (2022) "Epitope screening using Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS): An accelerated workflow for evaluation of lead monoclonal antibodies", Biotechnol J (link)
Lento C and Wilson DJ (2022) "Subsecond Time-Resolved Mass Spectrometry in Dynamic Structural Biology", Chem Rev (link)
2021
Duprez JS, Cohen M, Li S, Wilson DJ, Brookes RH and James DA (2021) "Immunocartography: Charting vaccine-driven immunity by applying single cell proteomics to an in vitro human model", J Immunol Methods (link)
Geib T, Lento C, Marensi V, Thulasingam M, Haeggström JZ, Olsson M, Wilson DJ, Leslie EM and Sleno L (2021) "Determining site occupancy of acetaminophen covalent binding to target proteins in vitro", Anal Sci Adv (link)
Oganesyan I, Lento C, Tandon A and Wilson DJ (2021) "Conformational Dynamics of α-Synuclein during the Interaction with Phospholipid Nanodiscs by Millisecond Hydrogen-Deuterium Exchange Mass Spectrometry", JASMS (link)
Narang D, James DA, Balmer MT and Wilson DJ (2021) "Protein Footprinting, Conformational Dynamics, and Core Interface-Adjacent Neutralization "Hotspots" in the SARS-CoV-2 Spike Protein Receptor Binding Domain/Human ACE2 Interaction", JASMS (link)
2020
Ausar SF, Zhu S, Duprez J, Cohen M, Bertrand T, Steier V, Wilson DJ, Li S, Sheung A, Brookes RH, Pedyczak A, Rak A and James DA (2020) "Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibits robust immunogenicity", Commun Biol (link)
Szymkowicz L, Wilson DJ and James DA (2020) "Development of a targeted nanoLC-MS/MS method for quantitation of residual toxins from Bordetella pertussis", J Pharm Biomed Anal (link)
Brown KA, Lento C, Rajendran S, Dowd J and Wilson DJ (2020) "Epitope Mapping for a Preclinical Bevacizumab (Avastin) Biosimilar on an Extended Construct of Vascular Endothelial Growth Factor A Using Millisecond Hydrogen–Deuterium Exchange Mass Spectrometry", Biochemistry (link)
Narang D, Lento C and Wilson DJ (2020) "HDX-MS: An Analytical Tool to Capture Protein Motion in Action", Biomedicines (link)
Nouchikian L, Lento C, Donovan K, Dobson R and Wilson DJ (2020) "Comparing the conformational stability of pyruvate kinase in the gas phase and in solution", JASMS (link)
Ahmadi S, Wu B, Song R, Zhu S, Simpson A, Wilson DJ, Kraatz HB (2020) "Exploring the interactions of iron and zinc with the microtubule binding repeats R1 and R4", J Inorg Biochem (link)
2019
Fontana K, Onukwue N, Sun B, Lento C, Ventimiglia L, Nikoo S, Gauld JW, Wilson DJ and Mutus B (2019) "Evidence for an Allosteric S-Nitrosoglutathione Binding Site in S-Nitrosoglutathione Reductase (GSNOR)", Antioxidants (link)
Miller JJ, Blanchet A, Orvain C, Nouchikian L, Reviriot Y, Clarke RM, Martelino D, Wilson DJ, Gaiddon C and Tim Storr T (2019) "Bifunctional Ligand Design for Modulating Mutant p53 Aggregation in Cancer", Chem Sci (link)
Huang X, Slavkovic S, Song E, Botta A, Mehrazma B, Lento C, Johnson PE, Sweeney G and Wilson DJ (2019) "A Unique Conformational Distortion Mechanism Drives Lipocalin 2 Binding to Bacterial Siderophores", ACS Chem Biol (link)
Geib T, Lento C, Wilson DJ and Sleno L (2019) "Liquid Chromatography-Tandem Mass Spectrometry Analysis of Acetaminophen Covalent Binding to Glutathione S-Transferases", Front Chem (link)
Szymkowicz L, Lento C and Wilson DJ (2019) "Impact of Cardiolipin and Phosphatidylcholine Interactions on the Conformational Ensemble of Cytochrome c", Biochemistry (link)
Masson GR, ..., Wilson DJ, ..., Schriemer DC and Rand KD (2019) "Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments", Nat Methods (link)
Ahmadi S, Zhu S, Sharma R, Wilson DJ and Kraatz HB (2019) "Interaction of metal ions with tau protein. The case for a metal-mediated tau aggregation", J Inorg Biochem (link)
Brown KA, Rajendran S, Dowd J and Wilson DJ (2019) "Rapid characterization of structural and functional similarity for a candidate bevacizumab (Avastin) biosimilar using a multipronged mass-spectrometry-based approach", Drug Test Anal (link)
Ahmadi S, Zhu S, Sharma R, Wu B, Soong R, Dutta Majumdar R, Wilson DJ, Simpson AJ and Kraatz HB (2019) "Aggregation of Microtubule Binding Repeats of Tau Protein is Promoted by Cu2+", ACS Omega (link)
Zhu S, Liuni P, Ettore L, Chen T, Szeto J, Carpick B, James AD and Wilson DJ (2019) “Hydrogen Deuterium Exchange Epitope Mapping Reveals Distinct Protective Mechanisms for Two Monoclonal Antibodies Against Diphtheria Toxin”, Biochemistry (link)
2018
Marella SA, Brown KA, Mansouri-Noori F, Porat J, Wilson DJ and Bayfield MA (2018) “An interdomain bridge influences RNA binding of the human La protein,” JBC (link)
Knox R, Lento C, and Wilson DJ (2018) "Mapping conformational dynamics to individual steps in the TEM-1 β-Lactamase catalytic mechanism", Journal of Molecular Biology (link)
Oganesyan I, Lento C, and Wilson DJ (2018) "Contemporary hydrogen deuterium exchange mass spectrometry", Methods (link)
Lugo MR, Lyons B, Lento C, Wilson DJ, and Merrill AR (2018) "Dynamics of Scabin toxin. A proposal for the binding mode of the DNA substrate", PLoS One (link)
Song E, Ramos SV, Huang X, Liu Y, Botta A, Sung HK, Turnbull PC, Wheeler MB, Berger T, Wilson DJ, Perry CGR, Mak TW, and Sweeney G (2018) "Holo-lipocalin-2–derived Siderophores Increase Mitochondrial ROS and Impair Oxidative Phosphorylation in Rat Cardiomyocytes", PNAS (link)
2017
Liuni P, Lento C, and Wilson DJ (2017) "Studying Enzyme Mechanisms Using Mass Spectrometry, Part 2: Applications" Chapter 8 in Mass Spectrometry in Chemical Biology: Evolving Applications, Editors: Norberto Peporine Lopes, Ricardo Roberto da Silva, Royal Society of Chemistry, ISBN: 978-1-78262-527-8 (link)
Lento C, Liuni P, and Wilson DJ (2017) "Studying Enzyme Mechanisms Using Mass Spectrometry, Part 1: Introduction" Chapter 7 in Mass Spectrometry in Chemical Biology: Evolving Applications, Editors: Norberto Peporine Lopes, Ricardo Roberto da Silva, Royal Society of Chemistry, ISBN: 978-1-78262-527-8 (link)
Deng B, Zhu S, Macklin AM, Xu J, Lento C, Sljoka A, and Wilson DJ (2017) "Suppressing Allostery in Epitope Mapping Experiments Using Millisecond Hydrogen/Deuterium Exchange Mass Spectrometry", mAbs (link)
Brown KA and Wilson DJ (2017) "Bottom-Up Hydrogen Deuterium Exchange Mass Spectrometry: Data Analysis and Interpretation", Analyst (link)
Zhu S, Khatun R, Lento C, Sheng Y, and Wilson DJ (2017) "Enhanced Binding Affinity via Destabilization of the Unbound State: A Millisecond Hydrogen / Deuterium Exchange Study on the Interaction Between p53 and a Pleckstrin Homology Domain", Biochemistry (link)
Resetca D and Wilson DJ (2017) "Mapping Ligand Binding Using Microfluidics-enabled Millisecond Timescale Hydrogen-deuterium Exchange", International Journal of Mass Spectrometry (link)
Lento C and Wilson DJ (2017) "Unravelling the Mysteries of Sub-second Biochemical Processes Using Time-Resolved Mass Spectrometry", Analyst (link)
Lento C, Zhu S, Brown KA, Knox R, Liuni P, and Wilson DJ (2017) "Time-resolved ElectroSpray Ionization Hydrogen-deuterium Exchange Mass Spectrometry for Studying Protein Structure and Dynamics", Journal of Visualized Experiments (link)
2016
Brown KA, Sharifi S, Hussain R, Donaldson L, Bayfield MA, and Wilson DJ (2016) "Distinct Dynamic Modes Enable the Engagement of Dissimilar Ligands in a Promiscuous Atypical RNA Recognition Motif", Biochemistry (link)
Balachandran N, Heimhalt M, Liuni P, Frederick To, Wilson DJ, Junop MS, and Berti PJ (2016) "Potent Inhibition of 3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) Synthase by DAHP Oxime, a Phosphate Group Mimic", Biochemistry (link)
Day C, Saldarriaga A, Tilley M, Hunter H, Organ MG, and Wilson DJ (2016) A Single-Stage, Continuous High-Efficiency Extraction Device (HEED) for Flow Synthesis", Organic Process Research & Development (link)
Deng B, Lento C, and Wilson DJ (2016) "Hydrogen Deuterium Exchange Mass Spectrometry in Biopharmaceutical Discovery and Development - A Review", Analytica Chimica Acta (link)
Donovan KA, Zhu S, Liuni P, Peng F, Kessans SA, Wilson DJ and Dobson RCJ (2016) "Conformational Dynamics and Allostery in Pyruvate Kinase", The Journal of Biological Chemistry (link)
Zhu S, Campbell JL, Chernushevich I, Le Blanc JC, Wilson DJ (2016) "Differential Mobility Spectrometry-Hydrogen Deuterium Exchange (DMS-HDX) as a Probe of Protein Conformation in Solution", JASMS (link)
Ball DP, Lewis AM, Williams D, Resetca D, Wilson DJ and Gunning PT (2016) "Signal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agent", Oncotarget (link)
Lento C, Ferraro M, Wilson DJ and Audette GF (2016) "HDX-MS and deletion analysis of the type 4 secretion system protein TraF from the Escherichia coli F plasmid", FEBS Letters, 590(3):376-86 (link)
Wilson DJ (2016) "Millisecond Hydrogen Exchange" Chapter 5 in Hydrogen Exchange Mass Spectrometry of Proteins: Fundamentals, Methods, and Applications, Editor: David D. Weis, John Wiley and Sons, Inc., ISBN: 978-1-118-61649-9 (link)
2015
Lento C, Wilson DJ and Audette GF (2015) "Dimerization of the type IV pilin from Pseudomonas aeruginosa strain K122-4 results in increased helix stability as measured by time-resolved hydrogen-deuterium exchange", Structural Dynamics (link)
Liuni P, Deng B and Wilson DJ (2015) "Comparing equilibrium and kinetic protein unfolding using time-resolved electrospray-coupled ion mobility mass spectrometry", Analyst (link)
Zhu S, Shala A, Bezginov A, Sljoka A, Audette G and Wilson DJ (2015) "Hyperphosphorylation of intrinsically disordered tau protein induces an amyloidogenic shift in its conformational ensemble", PLoS One (link)
Bao J, Krylova SM, Cherney LT, Le Blanc JC, Pribil P, Johnson PE, Wilson DJ and Krylov SN (2015) "Pre-equilibration kinetic size-exclusion chromatography with mass spectrometry detection (peKSEC-MS) for label-free solution-based kinetic analysis of protein-small molecule interactions", Analyst, 140(4):990-4 (link)
Eiring A, Page B, Kraft I, Mason C, Vellore N, Resetca D, et al. (2015) "Combined STAT3 and BCR-ABL1 Inhibition Induces Synthetic Lethality inTherapy-Resistant Chronic Myeloid Leukemia", Leukemia (link)
Lento C, Audette GF and Wilson DJ (2015) "Time-resolved electrospray mass spectrometry — a brief history", Canadian Journal of Chemistry (link)
2014
Liuni P, Romanov V, Binette MJ, Zaknoun H, Tam M, Pilon P, Hendrikse J and Wilson DJ (2014) "Unambiguous characterization of analytical markers in complex, seized opiate samples using an enhanced ion mobility trace detector-mass spectrometer", Analytical Chemistry, 86(21):10772-9 (link)
Resetca D, Haftchenary S, Gunning PT and Wilson DJ (2014) "Changes in signal transducer and activator of transcription 3 (STAT3) dynamics induced by complexation with pharmacological inhibitors of Src homology 2 (SH2) domain dimerization", The Journal of Biological Chemistry, 289(47):32538-47 (link)
Bao J, Krylova SM, Cherney LT, LeBlanc JC, Pribil P, Johnson PE, Wilson DJ and Krylov SN (2014) "Kinetic size-exclusion chromatography with mass spectrometry detection: an approach for solution-based label-free kinetic analysis of protein-small molecule interactions", Analytical Chemistry, 86(20):10016-20 (link)
Zinck N, Stark AK, Wilson DJ and Sharon M (2014) "An improved rapid mixing device for time-resolved electrospray mass spectrometry measurements", ChemistryOpen (link)
Liuni P, Zhu S and Wilson DJ (2014) "Oxidative Labeling with Mass Spectrometry for Studying Protein Structure, Folding, and Dynamics", Antioxidants and Redox Signalling (link)
2013
Rob T, Gill PK, Golemi-Kotra D and Wilson DJ (2013) "An electrospray ms-coupled microfluidic device for subsecond hydrogen/deuterium exchange pulse-labelling reveals allosteric effects in enzyme inhibition", Lab on a Chip, 13(13), 2528-32 (link)
Sljoka A and Wilson DJ (2013) "Probing Protein Ensemble Rigidity and Hydrogen-Deuterium exchange", Physical Biology, 10(5):056013 (link)
Resetca D and Wilson DJ (2013) "Characterizing rapid, activity-linked conformational transitions in proteins via sub-second hydrogen deuterium exchange mass spectrometry", FEBS Journal, 280(22), 5616-5625, front cover feature (link)
Liuni P, Olkhov-Mitsel E, Orellana A and Wilson DJ (2013) "Measuring Kinetic Isotope Effects in Enzyme Reactions Using Time-Resolved Electrospray Mass Spectrometry", Analytical Chemistry, 85(7), 3758-64 (link)
2012
Liuni P, Jaganathan A and Wilson DJ (2012) "Conformer Selection and Intensified Dynamics During Catalytic Turnover in Chymotrypsin", Angewandte Chemie Int. Ed., 51(38), 9666-9669 (link)
Rob T, Liuni P, Gill PK, Zhu S, Balachandran N, Berti PJ and Wilson DJ (2012) "Measuring Dynamics in Weakly Structured Regions of Proteins Using Microfluidics-Enabled Subsecond H/D Exchange Mass Spectrometry", Analytical Chemistry, 84(8), 3771-3779 (link)
Liang Y, Ore MO, Morin S, and Wilson DJ (2012) "Specific Disruption of Transthyretin(105-115) Fibrilization Using "Stabilizing" Inhibitors of Transthyretin Amyloidogenesis", Biochemistry, 51(16), 3523-3530 (link)
Rob T and Wilson DJ (2012) "Time-resolved Mass Spectrometry for Monitoring Millisecond Time-scale Solution Phase Processes", European Journal of Mass Spectrometry,18(2), 205-214 (link)
2011
Bao J, Krylova S, Wilson DJ, Reinstein O, Johnson P and Krylov SN (2011) "Kinetic Capillary Electrophoiresis with Mass-Spectrometry Detection (KCE-MS) Facilitates Label-Free Solution-Based Kinetic Analysis of Protein-Small Molecule Binding", ChemBioChem, 12(17), 2251-2254 (link)
Liuni P and Wilson DJ (2011) "Understanding and optimizing electrospray ionization techniques for proteomic analysis", Expert Review of Proteomics, 8(4), 197-209 (link)
Wilson DJ and Heffernan JM (2011) "The Undead: A Plague on Mankind or a Powerful New Tool for Epidemiological Research?" a chapter in Mathematical Modeling of Zombies, Editor: Robert Smith, University of Ottawa Press, Ottawa, ON.
2010
Liang Y, Jasbi SZ, Morin S, and Wilson DJ (2010) "Rational Manipulation of Amyloidogenesis Using an Atomic Level Map of Peptide-Fibril Interactions", Biochemistry 49(28), 5829-31 (link)
Liuni P, Rob T and Wilson DJ (2010) "A Microfluidic Reactor for Rapid, Low Pressure Proteolysis with On-Chip Electrospray Ionization", Rapid Communications in Mass Spectrometry, 24(3), 315 – 320 (link)
Wilson DJ (2010) "Microfluidic Devices for Studying Kinetics" Chapter 3 in Microfluidic Devices in Nanotechnology: Fundamental concepts, Invited, Editor: Challa Kumar, John Wiley and Sons, Inc., Hoboken, NJ.; ISBN: 978-0-470-47227-9 (link)
2009
Liang Y, Haftchenary S, Jasbi SZ, Morin S and Wilson DJ (2009) "Binding Interactions in Early and Late-stage Amyloids of TTR105-115", Biophysical Chemistry, 144(1), 1-8 (link)
Rob T and Wilson DJ (2009) "A Versatile Microfluidic Chip for Millisecond Time-Scale Kinetic Studies by Electrospray Mass Spectrometry", JASMS, 20(1), 124-30 (link)
Ferguson PL, Kuprowski MC, Boys BL, Wilson DJ, Pan J and Konermann L (2009) "Protein Folding and Protein-Ligand Interactions Monitored by Electrospray Mass Spectrometry", Current Analytical Chemistry, 5(2), 186-204 (link)
Konermann L, Pan J, and Wilson DJ (2009) "Biochemical Reaction Kinetics Studied by Time-Resolved Electrospray Ionization Mass Spectrometry" Chapter 5 in Protein Mass Spectrometry, Editor: J. Whitelegge. Series: Comprehensive Analytical Chemistry; Elsevier, Amsterdam, The Netherlands. ISBN-13: 978-0444530554