Ruth Knox
Ruth Knox
Ruth Knox

Background:

Ruth Knox is a 4th year PhD Candidate in the Wilson lab, specializing in using time-resolved HDX on catalytic systems. Her first (and upcoming second) publications with Dr. Wilson describe her work on TEM-1 beta-lactamase with a variety of drug substrates to influence future drug development. As part of the NSERC/CREATE grant Ruth received during her PhD, she was granted a technologist position at Sanofi Pasteur, working in the analytical research and development division on vaccine candidates. Her current project is focused on mapping the local dynamics of hydrogen tunneling in Yeast Alcohol Dehydrogenase (YADH) using HDX-MS. Outside of the lab, Ruth enjoys travelling, cooking, and all types of sports.

 

Education:

BSc, McGill University (Canada), 2011-2015. PhD, York University, Sept 2015-present.

 

Honours and Awards:

- NSERC/CREATE Grant, York University, 2015-present

- Graduate Entrance Scholarship, York University, 2015

- Canadian Society for Mass Spectrometry Student Travel Award, York University, 2017 and 2018

- President of the Graduate Management Consulting Association, York University, 2017-2019

- Gordon Research Conference Selected Presenter, Ventura, USA, 2017

- Poster Presentation Award, International Conference on Hydrogen/Deuterium Exchange (IC HDX), Sweden, 2017

- Tomlinson Engagement Award for Mentoring (TEAM) in Inorganic Chemistry, McGill University, 2014

 

Publications: 

Knox RLento C, and Wilson DJ (2018) "Mapping conformational dynamics to individual steps in the TEM-1 β-Lactamase catalytic mechanism", Journal of Molecular Biology, 430, 3311-3322.

Lento CZhu SBrown KAKnox RLiuni P, and Wilson DJ (2017) "Time-resolved ElectroSpray Ionization Hydrogen-deuterium Exchange Mass Spectrometry for Studying Protein Structure and Dynamics", Journal of Visualized Experiments, 122.

Lincoln R, Durantini AM, Greene LE, Martinez SR, Knox R, Becerra MC, and Cosa G (2016) "meso-Acetoxymethyl BODIPY Dyes for Photodynamic Therapy: Improved Photostability of Singlet Oxygen Photosensitizers," Photochemical & Photobiological Sciences, 16, 178-184.                      

 

Oral Presentations:

- International Mass Spectrometry Conference, Florence, Italy, August 2018. Mapping Conformational Dynamics to Binding Modes in TEM-1 β-lactamase Using Millisecond Scale ESI-MS

- Gordon Research Conference, Ventura, USA, March 2018  New Antibacterial Drug Discovery and Development Conference. 

 

Poster Presentations:

- International Conference on Hydrogen/Deuterium Exchange, Investigating Conformational Dynamics and Drug Binding Activity of TEM-1 β-lactamase Using Millisecond ESI-HDX-MS, 2017. 

- Canadian Chemistry Conference, Monitoring Residue-Specific Drug Interaction of TEM-1 -Lactamase Using Time-Resolved Hydrogen Deuterium Exchange Mass Spectrometry, 2017.

- International Mass Spectrometry Conference, Antibiotic Resistance and Enzyme Efficiency: Measuring Conformational Dynamics and Investigating Allosteric Hotspots of TEM-1 β-Lactamase Using Time-Resolved Hydrogen Deuterium Exchange Mass Spectrometry, 2016.